Reward Processing by the Opioid System in the Brain
نویسنده
چکیده
A. The endogenous opioid system and natural reinforcement 1383 B. The endogenous opioid system and drugs of abuse 1387 C. Perspectives: extending studies to animal models of drug addiction 1393 IV. Genetic Manipulation of the Opioid System, Reinforcement, and Drug Dependence 1393 A. Opioid receptor knockout mice 1393 B. Opioid peptide knockout mice 1394 C. Conclusion 1395 D. Perspectives: towards genetic manipulation of the opioid system in targeted neuronal populations 1395 V. Modifications of Opioid System Gene Expression Under Chronic Drug Exposure 1395 A. Opioid receptor mRNA levels 1397 B. Opioid peptide mRNA levels 1398 C. Conclusion 1400 D. Perspectives: adaptations of opioidergic systems, significance, and implications 1401 VI. General Conclusion 1401
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